Dupuytren’s disease, also known as Dupuytren’s contracture, is a progressive condition that affects the connective tissue (fascia) of the hand, beneath the skin of the palm and fingers. It is characterized by the formation of thickened, fibrous cords or nodules in the palm and fingers, which can gradually contract and pull the affected fingers into a bent or flexed position.
The exact cause of Dupuytren’s disease is not fully understood, but it is believed to involve a combination of genetic predisposition, environmental factors, and certain medical conditions. It tends to run in families and is more common in people of Northern European descent.
Dupuytren’s disease tends to target patients advancing in age, men, smoking, alcohol consumption, and certain medical conditions such as diabetes and epilepsy.
Dupuytren’s disease progresses slowly over time, with symptoms usually starting as small nodules or lumps in the palm that may initially be painless. As the disease advances, the nodules can develop into thick cords that extend into the fingers, causing progressive contracture and limiting the ability to straighten the affected fingers fully.
Common symptoms of Dupuytren’s disease include:
Nodules or lumps in the palm: Firm, raised nodules or lumps may develop in the palm, typically near the base of the fingers.
Cord formation: Thickened, fibrous cords may develop beneath the skin of the palm and extend into the fingers, causing contracture.
Finger contracture: The affected fingers may gradually become bent or flexed, making it difficult to fully extend or straighten them. This can affect hand function and make it challenging to perform everyday tasks such as gripping objects or shaking hands.
Tenderness or discomfort: Some patients with Dupuytren’s disease may experience tenderness, discomfort, or pain in the affected hand or fingers, particularly as the contracture progresses.